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101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6
2019 Aug 2
S-Ruxolitinib was initially developed to target the constitutive activation of the JAK-STAT pathway
A bis-Benzylidine Piperidone Targeting Proteasome Ubiquitin Receptor RPN13/ADRM1 as a Therapy for Cancer
CAS Number: 1425038-27-2
A-770041 vimopan monohydrate 101)86-72(95)56-24-28-60(29-25-56)89-40-38-88(39-41-89)47-57-46-76(6A 770041 is a potent ans selective LCK inhibitor. Concanavalin A stimulated IL 2 production in whole blood is inhibited by A 770041 with an EC50 of approximately 80 nM. A 770041 is orally bioavailable (F = 34. 1 + 7. 2% at 10 mg kg) and has a t(1 2) of 4. 1 + 0. 1 h. Concanavalin A induced IL 2 production in vivo is inhibited by oral administration of A 770041 (in vivo EC50 = 78 + 28 nM). A 770041 reverses paclitaxel and doxorubicin resistance in
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